The space-time continuum, or time-space continuum, (PROSE: Engines of War) was the term for the continuous set of coordinates created by the whole of space added to the whole of time.
The Time Vortex was the structure of the space-time continuum. (PROSE: The Crystal Bucephalus)
N-Space, which was the prime universe according to the Doctor, was comprised of eleven dimensions, including those comprising the space-time continuum. (PROSE: Parasite) The Doctor's TARDIS herself stated that she was an eleven dimensional being that existed across all space and time, (TV: The Doctor's Wife) while the Fifth Doctor referred to the ship as having an internal continuum. (AUDIO: The Butcher of Brisbane)
The Black Guardian explained that converting the sixth segment of the Key to Time before the fifth would rip apart the space-time continuum by causing a temporal quake. (AUDIO: The Destroyer of Delights)
A TARDIS could not receive power from the Eye of Harmony outside of the normal continuum. (PROSE: State of Change)
By the time continuum of the 20th century, Gallifreyan civilisation existed far in the past. (PROSE: Goth Opera)
The Interstitial Mass Transit System was formed by transdimensional tunnels which assaulted the space-time continuum on a level beyond human senses.
The Seventh Doctor stated that the Pythia's curse sent massive repercussions through the metareality of the space-time continuum. (PROSE: Transit)
Holes in the space-time continuum, rather than being outside of time and space, could lead to other universes. (PROSE: The Pit)
On the planet Utebbadon-Tarria, an experimental dimensional probe accidentally caused a localised inversion of the time-space continuum, causing it to resemble Hell. (AUDIO: Absolution)