The space-time continuum, or time-space continuum, (PROSE: Engines of War) simply refered to as the continuum, (COMIC: Follow That TARDIS!) was the term for the continuous set of coordinates created by the whole of space added to the whole of time.
N-Space, which was the prime universe according to the Doctor, was comprised of eleven dimensions, including those comprising the space-time continuum. (PROSE: Parasite) The Doctor's TARDIS herself stated that she was an eleven dimensional being that existed across all space and time, (TV: The Doctor's Wife) while the Fifth Doctor referred to the ship as having an internal continuum. (AUDIO: The Butcher of Brisbane)
The Black Guardian explained that converting the sixth segment of the Key to Time before the fifth would rip apart the space-time continuum by causing a temporal quake. (AUDIO: The Destroyer of Delights)
The Seventh Doctor warned El Ape against using a phosphorous grenade in Tunguska in 1908, claiming that it would "mess up the continuum". However, his warning came too late as the grenade caused a massive explosion. (COMIC: Follow That TARDIS!)
The Interstitial Mass Transit System was formed by transdimensional tunnels which assaulted the space-time continuum on a level beyond human senses.