This topic might have a better name.
Talk about it here.
Pandora's box was Amy Pond's favourite story as a child. She said the box contained "all the worst things in the world". (TV: The Pandorica Opens)
Martha Jones compared the transformation of Richard Lazarus via the hypersonic soundwave manipulator to Pandora's box, to which the Tenth Doctor concurred. (TV: The Lazarus Experiment)