Panama was one of the stops made by the Neptune on its around-the-world journey. (PROSE: Dateline to Deadline [+]Ian Farrington, Short Trips: Christmas Around the World (Short Trips, 2008).)
At one point, Daleks melting the ice in Antarctica led to a tidal wave in Panama which caused North and South America to be separated. (COMIC: Flood!!! [+]Terry Nation's Dalek Annual 1976 (Dalek annuals, World Distributors and Ltd, 1975).)
After being widowed, Mary Seacole opened a hotel in Panama at a time when it was considered the most dangerous and violent place on Earth. (AUDIO: The Charge of the Night Brigade [+]Error: Code 2 - no data stored in variables, cache or SMW.)