Mandrake, also known as M, was a drug that was exploited by the Mandragora Helix in the 1990s in an attempt to conquer Earth. On the dancefloor of the Falling Star nightclub, several 'lost souls' tried to give M to Muriel Frost and Jasper Bean. (COMIC: The Mark of Mandragora)
In 800, French king and Holy Roman Emperor Charlemagne lost a food taster to mandrake poisoning. (PROSE: The Lonely Computer)
In the 41st century, Erimem tricked Sekhmet into drinking her blood which was poisoned with distilled mandrake root that was contained in Erimem's signet ring. (AUDIO: The Bride of Peladon)