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Macbeth was a play, as well as the name of the titular regicidal thane, created by William Shakespeare.

The play featured three witches. (AUDIO: The Carrionite Curse)

It was considered bad luck to quote from Macbeth, or "the Scottish play", in a theatre. (AUDIO: The Book of Kells)

While it was an established fact that Shakespeare had embellished history for the sake of drama, much of the play appeared to be accurate. The play, was in essence, the retelling of an adventure of the Second Doctor, where he and his companions, Jamie McCrimmon and Zoe Heriot, accidentally became embroiled in the events of the play, taking on the roles of the witches, the murderers and Lady Macbeth's physician. At the end of this draft, the Doctor would make sure Shakespeare wrote the play correctly upon their next meeting. However, the play was later edited, possibly by Thomas Middleton, presumably for plausibility. (PROSE: The True Tragedy of Macbeth)

On 5 November 1605, the script of Macbeth was on a balcony of the Houses of Parliament. (GAME: The Gunpowder Plot)

In 1609, Macbeth was performed before King James I at Hampton Court Palace. The First Doctor and Vicki forced themselves on the stage, where they took on the roles of the Doctor and the Gentlewoman while confronting Shakespeare, who was playing Lady Macbeth. (PROSE: The Empire of Glass) The Fourth Doctor told Sarah Jane Smith that he played the part of the Doctor when the play opened at the Globe Theatre. (PROSE: Managra)

Robert Dodds believed his role as Banquo in the play to be his greatest triumph; most thought he was a poor actor. He was killed by Pamela whilst reciting his lines from the play. Two plaques with speeches from the play adorned Dodds' home, Banquo Manor. (PROSE: The Banquo Legacy)

At some point prior to 2606, the Galyari performed Macbeth on Berkoff IV. (AUDIO: The Crystal of Cantus)

During both his sixth and eighth incarnations, the Doctor superstitiously referred to it as "the Scottish play." (AUDIO: Medicinal Purposes, The Next Life, The Book of Kells)

While being tortured by Reverend Merodach in the Land of Fiction, the Doctor quoted the play. (AUDIO: Night's Black Agents)

After killing a Cyberman by using gold dust and a Cybermat, the Fourth Doctor quoted the play: "Dusty death. Out, out—". (TV: Revenge of the Cybermen)

The Sixth Doctor quoted the play by telling Peri Brown that what one says could be "a tale told by an idiot, full of sound and fury, but signifying nothing." (AUDIO: Whispers of Terror)

The Twelfth Doctor quoted the play by telling Clara Oswald and Jagganth Daiki-Nagata: "To die, to die. Glamis hath murdered sleep, therefore Cawdor shall sleep no more. Macbeth shall sleep no more." (TV: Sleep No More)

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