Dr Jeremiah O'Kane was the director of the Hawthorne clinic. He lived on the clinic's grounds in his retirement. The clinic had been run by his family for some time. Jeremiah's father, mother and two sisters had been murdered by Jeremiah's brother Daniel forty years before Liz Shaw arrived — the clinic was built in a place prone to evil, murderous possession of victims at certain times in history. The brother had been sent to an asylum following the murders, while Jeremiah took over the clinic. He also raised his deranged brother's son, Peter Russell, telling him only that he was adopted. Russell declined to enter the medical profession — a decision which drove a wedge between the two — but instead became a very wealthy businessman.

In his later years, O'Kane handed over the directorship to Dr Colin Dove. Despite his fading memory, he continued to act as a mentor to the doctors working there, including William Bruffin. O'Kane and Dove knew another cycle of evil was imminent and set up a bizarre experiment. They organised the return of O'Kane's brother as an inmate of the clinic. When the government's Care in the Community scheme forced the closure of hospitals, Russell stepped in to finance the clinic and keep it open. Apparently part of their plan, or certainly Dove's plan, was to bring the father and son together at the appointed time and create "perihelion" — allowing chaos to erupt into the world. Dove discussed this with O'Kane, but his involvement was questionable. O'Kane tried to mend fences with his returning adopted son, but it was only after Russell was possessed by the same evil spirit and his self-sacrificing father saved Liz Shaw from him, that "perihelion" was avoided and life returned to normal at the clinic. O'Kane and Russell tried to rebuild their relationship. (HOMEVID: The Zero Imperative)

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