Isabelle was the owner of the Galerie d'Art de Parisiennes. She sometimes gave tours of the gallery. After some troubles, she was forced to temporarily close the gallery.
In the spring of 1909, the gallery had its grand reopening. Isabelle greeted the Twelfth Doctor when he arrived at the event. Then she began giving a tour to some of the guests. As she approached Bridge over a Pond of Water Lilies, she was attacked by an alien and brought into the painting. The creature attempted to drain her life, but she escaped and found some other victims of the alien in a painting of Paris. The Doctor then joined them and used Isabelle's pen to draw a door back into reality.
She helped the Doctor find a bucket of white paint, which he used to trap the alien in a painting. Isabelle found the canvas covered in white paint to be a masterpiece and thanked the Doctor, claiming that it "[spoke] volumes about the war scene [that could be seen] peeking underneath". (COMIC: Gallery)