The International Space Station, or ISS, orbited Earth in the early 21st century. It was located 400 kilometres above the surface of the planet.

Canadian Chris Hadfield made a video of himself singing on the ISS, creating public interest in space exploration.

In 2015, the crew included Russian Dimitri Yemtov, South Korean Lee Jae-Yong, Cory, and Quinn led by Major Weir. That year, the ISS was destroyed by a Hyperion falling to Earth, killing the entire crew. (COMIC: The Hyperion Empire)

While rotating around the Earth in search of a time puncture, the Ninth Doctor, accompanied by Rose Tyler, had to fly the TARDIS fast enough to avoid detection by the International Space Station. The Doctor implied he had already sent the ISS at least one guitar, to buy their silence. On board the ISS, a woman briefly thought she had seen a blue light in her peripheral vision, as the TARDIS dematerialised. (PROSE: Rose and the Snow Window)

In the 2050s, the Tenth Doctor and Donna Noble visited the International Space Station, which was invaded by mange mites. (COMIC: Attack of the Mange Mites!)

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