On Miracle Day, Holly's brother Miles was shot and she discovered he had blogged about a conspiracy to end death a week before the Miracle. Holly teamed up with Miles' best friend Nick and Agent Joe Bradley of the FBI to discover the truth of the Miracle. Holly eventually tracked the key to the Miracle to Coney Island, but discovered to her horror that Nick was Miles' attacker. Nick forced Holly to help him locate the key to the Miracle, vats containing the blood of the immortal man who was now mortal. Holly shot Nick and his two goons with a hidden gun and was left with the decision of whether or not to destroy the blood as if the Miracle was negated, her cancer could return and Miles would likely die. Holly ultimately chose to destroy the blood.
After the negation of the Miracle, Holly continued to take care of Miles who had recovered enough from his wounds to survive the negation of the Miracle. Holly kept a bag of what appeared to be Jack's immortal blood in her refrigerator in case something happened to her or Miles. (WC: Web of Lies)