The Henrietta Street House was a brothel located on Henrietta Street in the 1780s which was owned by Scarlette. In 1782, the Eighth Doctor began living at Henrietta Street House after losing his TARDIS. He performed experiments with time in the House's cellar, eventually summoning his companions Fitz Kreiner and Anji Kapoor to the House, then his TARDIS.

In 1783, the Doctor fought the King of Beasts at the Henrietta Street House.

In late 1783, Scarlette gave the House to Lisa-Beth Lachlan, who ran it until 1789, at which point she disappeared. Rebecca Macardle also left the House in 1789. In their absence, the House eventually closed down, having served its purpose. By the mid-20th century, the former site of the Henrietta Street House was occupied by an occult shop (PROSE: The Adventuress of Henrietta Street) owned by Lady Diamond. (PROSE: Dead Romance)

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