Grace was interested in the American Civil Rights Movement and was inspired in particular by the deeds of Rosa Parks and Martin Luther King, owning a t-shirt that said "the Spirit of Rosa". (TV: Rosa) Grace loved watching period dramas with posh country estates on telly. (PROSE: The Secret in Vault 13)
In 2012, after his mother passed away, Grace came to raise her 13-year-old grandson, Ryan Sinclair. (TV: The Woman Who Fell to Earth, The Tsuranga Conundrum) She told him the fable of The Lion and the Mouse, (PROSE: The Good Doctor) and would often attempt to teach Ryan how to ride a bicycle, which he struggled with because of his dyspraxia and he kept losing his balance. (TV: The Woman Who Fell to Earth) Despite her son's inaction with Ryan, Grace continued to keep his old things. (TV: Resolution)
Grace worked as a chemo nurse. It was during this line of work that she met cancer patient Graham O'Brien, to whom she became attracted to. (TV: The Woman Who Fell to Earth) When she learned that Graham was a bus driver, she remarked that he ought not to be like James Blake, who she called "Blake the snake". (TV: Rosa) After his cancer went into remission, Graham and Grace married in 2015. (TV: The Woman Who Fell to Earth)
She wanted Ryan to consider Graham his granddad even though Ryan continually resisted. (TV: The Woman Who Fell to Earth) On Christmas 2016, Graham and Ryan unknowingly both gifted Grace a different frog necklace, because they knew she liked frogs and had failed to communicate with each other. (TV: It Takes You Away)
In September 2018, whilst returning home after an unsuccessful session of bike riding with Ryan, Grace and Graham were trapped when a swarm of gathering coils attacked their train in search of Karl Wright, a fellow passenger. She, along with Graham, Ryan and Yasmin Khan, helped the Thirteenth Doctor battle both the coil and its controller, Tim Shaw.
While the Doctor was recovering from her recent regeneration, she slept on the sofa in Grace and Graham's home, with Grace and Ryan witnessing the residual regeneration energy swirling around the Doctor's body. Grace felt her wrist and realised that the Doctor had a double pulse. Later, Grace and Graham followed the Doctor's orders to pose as construction managers and evacuate the construction site Karl worked at, so the Doctor, Ryan and Yasmin could rescue him.
However, the gathering coils were still active, with Tim Shaw using them to damage the crane that Ryan and the others were on. Despite Graham's protests, Grace climbed up and destroyed the creature by electrocuting it with live cables. However, Grace was also electrocuted in the process and fell to the ground. Mortally wounded, she died in Graham's arms, after telling him to not be afraid without her. Graham later spoke of how Grace inspired him during their three-year marriage at her funeral. (TV: The Woman Who Fell to Earth)
In response to his grief, Graham had several visions of Grace in the house where the couple had lived together with Ryan. He told the Doctor that he didn't want to stay at home, haunted by memories of all he had lost, and he instead wanted to travel with her. Graham's travels in the TARDIS helped him cope. (TV: Arachnids in the UK) Graham wore Grace's frog necklace as a way of keeping her close. (TV: It Takes You Away)
The Solitract took the form of Grace in order to try to convince Graham to stay in the Solitract plane, but Graham saw through the deception, as the Grace duplicate showed a lack of concern for Ryan when he was trapped in the anti-zone, which was something that Graham knew the real Grace would never do. The Solitract, when talking with the Doctor in the form of a frog used Grace's voice. Afterwards, Ryan comforted Graham, telling him that he thought about Grace all of the time too and accepting Graham as his grandfather for the first time. (TV: It Takes You Away)
After arriving on Ranskoor Av Kolos, Team TARDIS was shocked to discover Tzim-Sha on the planet. Graham sought to kill the Stenza warrior to avenge Grace while Ryan argued against it, feeling that Grace would've wanted Graham to "be the better man," something that she often told them to do. When finally confronted by Tzim-Sha, Graham couldn't bring himself to kill him and instead did what Grace would've wanted and was the better man in the situation. Instead, Graham and Ryan subdued Tzim-Sha and sentenced him to life imprisonment in a Stenza stasis chamber, used by Tzim-Sha for Stenza trophies. As Grace's husband and grandson placed her killer into stasis, they ordered him to hold Grace's name in his mind as he contemplated eternity. (TV: The Battle of Ranskoor Av Kolos)