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Exxilon may refer to:
- Exxilon, the planet.
- Exxilons, the species.
- Exxilon (story), a short story written by Sarah Jane Smith.
- The Great City of the Exxilons, sometimes called the Exxilon City.
- The antibodies for the Great City.
- Sexxilon, an unrelated planet once visited by Iris Wildthyme.