Comic stories have appeared in all issues of Doctor Who Magazine in some form. Since its earliest days as Doctor Who Weekly, the publication has been home to many types of strips, but the most durable has been the one featuring the then-current televised Doctor. This "main strip" has usually been told in a multi-part format. Beyond these continuing adventures of the Doctor, the magazine has at different times printed comic adaptations of classic science fiction stories, reprints of original science-fiction stories from American comic book anthologies, reprints of strips originally printed in Polystyle or City Magazines publications, and original strips not featuring the Doctor which were nevertheless set in the Doctor Who universe.
At the same time, those early issues of Doctor Who Weekly brought American comic strips in front of British eyes by having a long series of reprints taken straight from Marvel's long line of American science fiction anthologies. Called variously Tales from the TARDIS and Dr Who's Time Tales, the non-Whoniverse backup strips of those early issues involved a few panels of the Fourth Doctor framing a Marvel US adaptation of a classic science fiction story or an original strip taken from a Marvel US science fiction anthology of the 1950s or 1960s. Borrowed as they were from Marvel US, they featured the talents of Marvel legends Steve Ditko, Jack Kirby, Chris Claremont, and even Stan Lee himself. Skinn also resurrected the long-out-of-print Dalek Tapes stories that had originally appeared in TV Century 21. For a time, Doctor Who Weekly regularly had three or four different strips in each issue.
Skinn's successors rather quickly ended the non-Whoniverse material, and made reprints of 1960s material increasingly sporadic. But the non-Doctor original back-ups remained well past the time the magazine became Doctor Who Monthly. These backups, however, dried up at about the time the Sixth Doctor debuted. By the end of the 1980s, the magazine generally ran only the main Doctor Who strip. However, there were rare instances when a Polystyle comic made its way into print during the 1990s. These occasional reprints ended entirely by the dawn of the 21st century. In 2017 a reprinted collection of the Polystyle comic strip *Sub Zero was included free inside the polybag of the 1970s themed issue 508, but this was an additional entity to the magazine issue itself. Similarly, in 2020 reprints of the Polystyle comic strips The Glen of Sleeping and Fogbound were included free as two of the reprinted strips in the Past Masters supplement which came with issue 547, but again this was in an additional entity to the magazine issue itself.
Over issues 475 and 476 in 2014, the sole comic strip other than Doctor Whoah! in issue 475 was a Doctor-less story called The Crystal Throne. This comic story was published after the Eleventh Doctor's final comic strip in the magazine and before the Twelfth Doctor's DWM debut, and instead featured Vastra, Jenny Flint and Strax, who appeared in several episodes of the Doctor Who TV series between 2011 and 2014.
Since 2017, Doctor Who Magazine has published the main eight-page comic strip, along with a three-panel parody called The Daft Dimension, the latter of which since 2014 was usually printed in the pages of the magazine's Galaxy Forum feature. The main comic had previously run to as many as 12 pages, with the 500th issue story The Stockbridge Showdown being 20 pages long.
As has been the case since 1979, most stories in the main strip are serialised and told over the course of several issues, with the occasional single-chapter standalone. Originally published in black and white, the comic strip has been published in colour since DWM 300 in 2001.
The main strip was forced to take a three-issue break in 2020 due to the difficulty of producing issues remotely during the COVID-19 pandemic, with issues 553 through 555 lacking a main comic story beyond the usual The Daft Dimension gag strip. (Previous breaks with no non-gag comic were DWM 163, 261, and 354.) It returned with Monstrous Beauty, a three-issue story running from issues 556 to 558 featuring the Ninth Doctor and Rose which tied into the Time Lord Victorious series, before returning to the Thirteenth Doctor afterwards.
Doctor Who Magazine material was first reprinted in America via the Marvel Premiere anthology series in the early 1980s. When sales proved favourable, a new title, Doctor Who (1984), was launched. Though cancelled just shy of its two-year anniversary, the title managed to reprint almost all of the Fourth and Fifth Doctors' DWM runs. It also offered some prominent American artists, such as Dave Cockrum and George Roussos, an opportunity to offer pinup and cover artwork of Doctor Who subjects. Like many DWM reprints, Doctor Who (1984) presented its reprints in colour.
Towards the end of 2007, IDW Publishing picked up the option to again reprint colourised versions of DWM comic strips in a monthly American series entitled Doctor Who Classics, reprinting stories up to the early Seventh Doctor era, plus a two-volume standalone, Grant Morrison's Doctor Who, reprinting Morrison's output from DWM. IDW also published several omnibus trade paperbacks featuring DWM strip reprints. The reprints ended with IDW's loss of their license to publish Doctor Who comics.
As a result of being colourised by separate reprint publications, a handful of stories have been colourised differently up to three times.
In the UK, Panini Comics undertook a long project to digitally restore all Doctor Who Magazine comics, and faithfully reprint the comics from their original masters. In most cases, this has meant the first monochromatic reprinting of most DWM strips. It has also offered the creative teams an opportunity to add explanatory notes and original concept artwork. These large-format volumes have to date covered most of the history of DWM from 1979 onwards.