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Cholera was a disease which threatened the town of Mercy, Nevada before it was cured by Kahler-Jex. The Kahler found a cure for the disease centuries before 1870. Jex described the disease as a "minor infection". (TV: A Town Called Mercy)

During the Miracle in 2011, cholera had spread to Boston. (TV: Escape to LA) It was among the diseases which caused a lockdown at the Cowbridge Overflow Camp. (TV: The Categories of Life)

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