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Mrs Angelo was a resident of Leadworth, Gloucestershire, England, and the grandmother of Jeff Angelo.

When Amy Pond and Rory Williams were children, Mrs Angelo once found Rory in her garden, who had gotten lost while playing blind man's buff. (WC: The Raggedy Doctor by Amelia Pond)

In 2008, she was disturbed when the Atraxi hijacked and appeared on her television and even more so when Amy and the newly regenerated Eleventh Doctor burst into her home. She commented that she had seen the Doctor before, but he replied that it was not him, because he had just regenerated. Later, when the Doctor had a conference call with several alien experts, Mrs Angelo expressed her interest in Sir Patrick Moore (TV: The Eleventh Hour)

Mrs Angelo wore a broach which appeared to be similar to, or identical to, a broach worn by River Song at Amy and Rory's wedding reception. (TV: The Big Bang)

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