Grace O'Brien

Grace O'Brien was the paternal grandmother of Ryan Sinclair. She lived in Sheffield with her second husband, Graham O'Brien, whom she met during her work as a chemo nurse. Grace would often attempt to teach Ryan how to cycle, which he struggled with because of dyspraxia.

Whilst returning home after an unsuccessful session, Grace and Graham were trapped when a swarm of gathering coils attacked their train in search of Karl Wright, a fellow passenger. She, along with Graham, Ryan and Yasmin Khan, helped the Doctor battle both the coil and its controller, Tzim-Sha.

While the Doctor was recovering from her recent regeneration, she slept on the sofa in Grace and Grahams' home, and Grace and Ryan witnessed the residual regeneration energy swirling around the Doctor's body, and Grace felt her wrist and announced she had a double pulse. Later, Grace and Graham followed the Doctor's orders to pose as construction managers and evacuate the construction site Karl worked at so the Doctor, Ryan and police officer Yasmin could rescue him. However, the gathering coils were still active, Tzim-Sha using them to damage the crane Ryan and the others were on. Despite Graham's protests, Grace climbed up and destroyed the creature via electrocution. Although, Grace was electrocuted in the process and fell. Mortally wounded, she died in Graham's arms, telling him to not be afraid without her. Graham later spoke of how Grace inspired him during their three year marriage at her funeral. (TV: The Woman Who Fell to Earth)