Regeneration


 * This article is about the Time Lord physiological process. For other uses of Regeneration, see Regeneration (disambiguation)

Regeneration was the process by which Time Lords could renew themselves, causing a complete physical (and often, emotional) change. It happens either at will or because of severe illness or injury.

Scientific explanation
Different explanations were given for the process behind regeneration.


 * One explanation was that Cardinal Rassilon had been investigating a method of regenerating decaying and diseased tissue via a series of permanently carried, self-replicating, biogenic molecules. The cells of a Gallifreyan body could be repaired, restored and re-organised. This would result in a wholly new physical form. The brain cells would similarly be rearranged, though to a lesser degree, thus ensuring the new incarnation would replicate the memories and personality of the former incarnation. Rassilon intended for this mechanism only to be used upon the Gallifreyan elite. He also inputted a parameter of 12 regenerative cycles to avoid decaying biogenic molecules. (BFA: Zagreus)
 * Another theory attributed regeneration to a "nanomolecular virus" that rebuilt the body much like the "self-replicating biogenic molecules". (REF: The Gallifrey Chronicles)
 * A third theory was that Time Lords had triple-helix DNA: the third strand was added by Rassilon to make regeneration possible. (MA: The Crystal Bucephalus)
 * One partial explanation of the process linked it to the release of massive amounts of a hormone known as lindos at moments of extreme trauma, with the hormone triggering the regeneration itself. Recently-regenerated Time Lords could be identified by the raised levels of lindos in their system. (DWN: The Twin Dilemma, BFA: Unregenerate!)
 * At one point it was stated that Time Lords had "packets" of regeneration energy within their bodies, one for each life. These packets could be physically removed from a Time Lord's body, essentially robbing them of their regenerations. (DW: Mawdryn Undead)

Physical and mental change
During the process of regeneration, there were the genetic equivalent of 'bit errors' in the DNA of the regenerated cells. This caused the appearance of the Time Lord to change, causing changes in appearance, height, mass or apparent age. The personality would also change, because even the cells and chemistry of the brain regenerated as well. Although the aspects of their personality caused by "nurture" would not change, the "nature" contribution to their personality would change. (BFA: The Sirens of Time) One, albeit dubious, source states that Time Lords of the Oldblood Houses, born with just one heart, grew a second heart upon regeneration. This included the Doctor, who in his first incarnation had only one heart. (MA: The Man in the Velvet Mask) According to the Doctor, every regeneration was painful. (SJA: Death of the Doctor)


 * When one of the Doctor's hearts stopped he wondered aloud how humans could cope with just one, suggesting he had never experienced a single heartbeat. (DW: The Shakespeare Code) However as he was in his tenth incarnation at the time, it may have been so long since he last had the experience he may have forgotten what it was like.

More extreme changes were possible. One Time Lord was able to regenerate a complete body after being decapitated, but the process was cut short when stabbed through both hearts. (EDA: The Shadows of Avalon) The Eleventh Doctor feared that he had become a woman, (DW: The End of Time) while the Ninth Doctor suggested two heads or no head were possible (DW: The Parting of the Ways). Later comments by his eleventh incarnation stated clearly that he could become "anything". (SJA: Death of the Doctor) The Corsair was a Time Lord/Time Lady who the Doctor claimed to have known as both sexes. (DW: The Doctor's Wife)

All known naturally occurring Time Lord regenerations remained humanoid, with all vital limbs and organs in place. Nonetheless, the Doctor's eleventh incarnation made it a priority - even amidst serious damage to his TARDIS - to immediately conduct a physical inventory to make sure he still had two legs and sufficient fingers, eyes, ears, a nose, chin and hair. (DW: The End of Time)


 * The Doctor's ability to regrow a severed limb soon after regeneration (DW: The Christmas Invasion) suggests the possibility that had the eleventh incarnation, for example, discovered a deficiency - a missing leg, for example - he might have been able to rectify the situation.

Appearance
During a regeneration, the Time Lord's body shone with milky white light (DW: Logopolis, Time and the Rani, Doctor Who) or with a violent-seeming discharge of bio-energy. (DW: The Parting of the Ways, Utopia, The Stolen Earth, The End of Time, The Impossible Astronaut). In other cases, there was no visible energy discharge. (DW: Planet of the Spiders, Destiny of the Daleks)
 * The colour of bio-energy released during regeneration may be different between individual Time Lords, as the Doctor's have released golden-orange energy while the Master's released brilliant white energy.

Just prior to his ninth regeneration, the Doctor warned his companion to keep away from him. (DW: The Parting of the Ways, The Stolen Earth) The damage done to the TARDIS during the Tenth Doctor's regeneration into the Eleventh (enough to force a complete reconstruction) may have been an example of the potential dangers the regeneration energy could pose to those who stand too close. (DW: The End of Time) However, other regenerations occurred with other individuals seen in close proximity. (DW: The Tenth Planet, Planet of the Spiders, Logopolis, The Caves of Androzani, Time and the Rani)

After-effects
During the first few hours of the regeneration, the Time Lord would often suffer from confusion, erratic behaviour and memory loss. The Time Lord might have difficulty "steering" their new body, and might also suffer random spasms as the regeneration settled. (DW: The Eleventh Hour) The Doctor, in particular, though not so much other Time Lords, exhibited mood swings and confusion. It took some time for his newly-regenerated fifth incarnation to remember his own identity. (DW: Castrovalva) On one occasion, he attempted to strangle Peri to death before re-asserting control of himself (DW: The Twin Dilemma) and on another he almost crashed the TARDIS. (DW: Children in Need Special) Following his tenth regeneration, the Doctor experienced powerful, rapidly alternating food cravings, declaring a certain type of food his favourite one minute, and saying he hated it the next. (DW: The Eleventh Hour)

A Zero Room could help with the process, as it removed all outside distractions. (DW: Castrovalva) After his first regeneration, the Second Doctor implied that his TARDIS helped the process along. (DW: The Power of the Daleks) For other species, a metamorphic symbiosis regenerator was said to be able to provide help when regenerations failed, though whether this true for Time Lords is unknown. (DW: Mawdryn Undead)

Were a Time Lord knocked unconscious, the whole process might be started all over again (DWN: The Power of the Daleks), but this was not a certainty (DW: The Eleventh Hour). If the Time Lord was fatally injured a second time during the regeneration, they would die; the body died from the initial injury, but would be unable to complete the regeneration. (DW: The Impossible Astronaut)

After a while, the Time Lord's body would have settled down, though they could regrow limbs within the first 15 hours of the regeneration due to having enough residual energy. (DW: The Christmas Invasion) Even after the physical transformation, changes might occur. The Doctor appeared to be excessively tired after his third regeneration, deliberately falling asleep in many odd locations. (DW: Robot) The Fifth Doctor's hair went from longer to shorter to longer in the space of a few days. (MA: Cold Fusion) For a short time after regenerating, a Time Lord displayed greater strength than usual; The Doctor's fourth incarnation was able to karate-chop a brick in half while recovering from his regeneration (DW: Robot), his eighth incarnation managed to break down a steel door bare-handed immediately following his. (DW: Doctor Who) and his Eleventh Incarnation was able to hold his own weight while his tardis was spiralling out of control through the air, with just his fingers. (DW: The Eleventh Hour)

Some Time Lords, however, might regenerate with little or no overt complications, for example, Romana. (DW: Destiny of the Daleks)

Limitations
Though Time Lords could regenerate after severe injuries, regeneration did not seem to be guaranteed. Maxil implied that a fatal blast from a staser (an energy weapon used by the Chancellory Guard on Gallifrey) could prevent regeneration. (DW: Arc of Infinity) Stabbing or shooting a Time Lord through both hearts at the same time (EDA: The Shadows of Avalon, PDA: World Game), burning out both hearts (DW: Silence in the Library / Forest of the Dead) or drowning, if it happened quickly enough (DW: Turn Left) could also end a Time Lord's life regardless of how many regenerations they had left. Acid could also destroy the ability to regenerate. (NSA: Night of the Humans). If the regeneration was interrupted with a fatal injury, the regeneration would fail. (DW: The Impossible Astronaut)

As well, the interference of some medications, such as anaesthesia, might disrupt or destroy the regenerative process. (DW: Doctor Who)

Regenerative cycle
The Time Lords had a limited regenerative cycle of twelve regenerations, consisting of thirteen incarnations, after which they had no more regenerations and would suffer permanent death. (DW: The Deadly Assassin, Doctor Who) Time Lords could will themselves to die by regenerating when they had no more regenerations left to use, as Azmael chose to do. (DW: The Twin Dilemma) Rassilon apparently had physical reasons to impose this restriction. (BFA: Zagreus)

As with most such "rules" there were occasionally exceptions to the twelve regeneration limit. The High Council, offered the Master a new regenerative cycle if he complied with rescuing the various incarnation of the Doctor from the Death Zone. (DW: The Five Doctors) Although he did not receive this award on that occasion, during the Last Great Time War the Master was given the ability to regenerate at least once more. (DW: Utopia)

In his Eleventh incarnation, the Doctor claimed he could regenerate 507 times. (SJA: Death of the Doctor) However whether the Doctor was speaking the truth, or was simply trying to showoff is up to debate.

Control over regeneration
Generally, regeneration was initiated when a Time Lord was too badly injured to survive. However in some cases Time Lords were known to exercise control over the process. Romana appeared to regenerate on a whim, (DW: Destiny of the Daleks) while Azmael initiated a thirteenth regeneration in order to end his life (DW: The Twin Dilemma).

The degree of control that Time Lords had over their end appearance was unclear. The Master was able to make his next regeneration as young as the Tenth Doctor appeared at the time, though since most regenerations led to younger bodies this may have been a coincidence. (DW: Utopia) Romana seemed adept enough at the process to custom design her new appearances, trying several bodies before finally deciding on a copy of Princess Astra. The Doctor criticised Romana for taking on the form of another person, suggesting such things were not unheard of. (DW: Destiny of the Daleks) In contrast to Romana, the Doctor did not appear to have much control over his post regeneration appearance; after his fourth regeneration he commented "that's the problem with regeneration, you never quite know what you're going to get" (DW: Castrovalva), and would restate this immediately prior to his ninth regeneration (DW: The Parting of the Ways)
 * However as the Doctor's regenerations have thus far either been forced on him or been triggered when an incarnation has been mortally wounded, it may be that the appearance of the next incarnation can be controlled if the regeneration is voluntarily triggered (as was Romana's).



While skilled Time Lords could choose their new form with a voluntarily induced regeneration, the process had the potential to go horribly wrong and leave the Time Lord in a severely misshappen body. The problem was then often exacerbated by the Time Lord trying to solve the problem by immediately starting another regeneration instead of obtaining medical assistance, which only amplified the defects in the regeneration. The end result of several too close regenerations, whether self-initiated or not, was inevitably a mutated monstrosity that could only be put out of its misery by complete disintegration. (DWN: The Twin Dilemma)

Some Time Lords were capable of momentarily regenerating, or partially regenerating. Though this could use up a lot of regenerative energy, it could give the Time Lord a new set of genes, allowing them to fool genetic sensors. The Seventh Doctor used this method on the planet Purgatory in order to fool the genetic scanner used by the Landsknechte. (NA: Original Sin)

The Time Lords were apparently capable of controlling the regeneration of individual Time Lords, either forcing a regeneration, influencing the new appearance (DW: The War Games) or removing later regenerations (DW: The Ultimate Foe).

With some difficulty, Time Lords could resist regeneration, thereby effectively committing suicide. (DWN: The Power of the Daleks) The Master did so after being shot, ostensibly to avoid becoming the Tenth Doctor's eternal prisoner. (DW: Last of the Time Lords) Similarly, the Fifth Doctor once threatened System with resisting regeneration in order to stop the device from learning the biological details of the act. (BFA: The Gathering) This was not always an option, however, as the Doctor noted fearfully that while his companion could die only once, he might have to repeatedly regenerate and live out all of his life times when the TARDIS stalled in the middle of space. (DW: Vengeance on Varos) At the very least, the Tenth Doctor was able to resist the regenerative process long enough to revisit each of his former companions (both those of his own incarnation and his past selves as well). (DW: The End of Time, SJA: Death of the Doctor)

Regenerative difficulty
While most regenerations seemed to cause moments of mental instability (with some degree of temporary amnesia often noted), some offered particularly profound instances of physical peril. The Fifth Doctor feared that his fourth regeneration "was failing" when he found himself reverting to previous personas, and could only be righted with the use of the Zero Room of the TARDIS. (DW: Castrovalva) Later, the Eighth Doctor claimed that anesthesia had "nearly destroyed the regenerative process" during his seventh regeneration, as a possible explanation for the particularly severe amnesia he suffered afterwards. (DW: Doctor Who) Still later, one of the Tenth Doctor's hearts stopped beating for a prolonged period of time, and he began to exhale regenerative energy when his ninth regeneration went "a bit wrong", after which he slipped into a coma-like state for most of a day. (DW: Children in Need Special, The Christmas Invasion)

Meta-crisis
A Time Lord could prevent death and regeneration by focusing the regenerative energies into a severed appendage, like the Doctor's hand. His hand siphoned off the excess energy that would have changed his appearance while the Tenth Doctor used just enough to heal himself from the injury sustained by a Dalek Gunstick. This resulted in the appendage storing enough energy to actually grow an identical Time Lord after it came in contact with Donna Noble. As a consequence, the Doctor appeared to regenerate and heal but did not change. (DW: Journey's End)


 * It is unknown if this used up one of the Doctor's regenerations.

Cross-species transformations
I.M. Foreman, a Gallifreyan (but not a Time Lord), absorbed the DNA around him and underwent indescribable changes as a result of mutations, transcending sex, species and even physical existence itself. (EDA: Interference - Book One, Interference - Book Two) Romana, prior to her regeneration into her second incarnation, appeared to have taken on a near-human blue-skinned form. (DW: Destiny of the Daleks)


 * One account states that the TARDIS itself, rather than Romana, adopted this shape. (ST: The Lying Old Witch in the Wardrobe)

Aborted regeneration
Occasionally, a regeneration would fail and the regeneration would abort. Though the Time Lord would have regenerated, they would be severely deformed. Though Time Lord technology could treat this, on some occasions the damage could be too severe to fix.

After being shot by the War Lords, the War Chief was barely able to survive. While being taken back to the War Lords' planet, his body attempted to regenerate. Due to the massive injuries and the lack of medical care, this regeneration aborted, which meant he had two conjoined individual bodies, poorly fused together (NA: Timewyrm: Exodus).

Attitude toward regeneration
As noted above, regeneration was not guaranteed, as the Doctor on numerous occasions believed he was in danger of actually dying. Even with regeneration a possibility, the Doctor came to consider such a change as being nonetheless a "death". In recollecting the events surrounding the Master's attempt at stealing the Eye of Harmony, the Eighth Doctor referred to his incarnations as "lives". (DW: Doctor Who: The Movie) Time Lords such as the War Chief were unconcerned about wasting regenerations, while others such as the Doctor warned not to waste them. (MA: Invasion of the Cat-People) Iris Wildthyme once confided in Samantha Jones, saying that regeneration was treated on Gallifrey the same way sex was on Earth. (EDA: The Scarlet Empress)

The Doctor's opinions towards regeneration seemed to change in his later regenerations, considering it more like true death. In his ninth incarnation, the Doctor bade farewell to his companion, ("I'm not gonna see you again. Not like this.") even though he was not actually dying. (DW: The Parting of the Ways) The Doctor's tenth incarnation was concerned about a prediction made regarding his own impending regeneration, saying "Even if I change, it feels like dying. Everything I am dies. Some new man goes sauntering away...and I'm dead." (DW: The Waters of Mars, The End of Time)

Regeneration in other species
On several occasions, individuals of other species (or even artificial life) were capable of regeneration. In most cases, this ability was copied from the Time Lords.


 * The crew of the Minyans' ship, the P7E, were capable of regenerating themselves indefinitely, likely as a result of the interference by the Time Lords in their early history. Over time, they wearied of life. (DW: Underworld)
 * Mawdryn and his followers, who had stolen the Time Lords' regeneration technology, also had an apparently limitless number of incarnations, though they had no control over when it would happen and what form, often grotesque, they would change into. Consequently, they also longed for death, making their mutations a kind of de facto punishment by the Time Lords for stealing their technology. (DW: Mawdryn Undead)
 * Chris Cwej was regenerated by force to survive radiation poisoning. (BNA: Tears of the Oracle)
 * K9 Mark I regenerated by use of a Regeneration unit after self-destructing to defeat a group of Jixen Warriors. (K9TV: Regeneration) He later regenerated again after exhausting power core to defeat the Trojan. (K9TV: The Eclipse of the Korven)
 * The Cinder was a sentient spark which grew into a Phoenix made of living flame. When extinguished, it was able to slowly regenerate from a single surviving spark of itself back into its Phoenix form. (CC: Frostfire)

The Doctor

 * First to second incarnation: Grew increasingly ill as Mondas drained his energy as well as Earth's, coupled with his body's advanced age (DW: The Tenth Planet)
 * Second to third incarnation: Enforced upon him by the Time Lords as a punishment (DW: The War Games)
 * Third to fourth incarnation: Exposure to The Great One's highly unstable web of Metebelis crystals. (DW: Planet of the Spiders)
 * Fourth to fifth incarnation: Plummeted from the Pharos Project radio telescope. (DW: Logopolis)
 * Fifth to sixth incarnation: Suffered the consequences after coming into contact with unrefined spectrox. (DW: The Caves of Androzani)
 * Sixth to seventh incarnation: Body devastated by Chronon energy he absorbed whilst in the Spiral Chamber (Spiral Scratch)
 * Seventh to eighth incarnation: Injured in the crossfire of a gang war and raced to hospital where the surgeons attempted to explore his unearthly physiology, only succeeding in damaging his cardiovascular system far beyond repair (DW: The TV Movie)
 * Eighth to ninth incarnation: Unknown, but involved the Last Great Time War. (IDW: The Forgotten)
 * Ninth to tenth incarnation: Cellular degeneration caused by absorbing the energies of the time vortex from Rose Tyler to both save her life and restore the TARDIS (DW: The Parting of the Ways)
 * During tenth incarnation: Partial regeneration after being hit by Dalek fire (DW: The Stolen Earth); aborted by channeling the energy into his severed hand, leading to the two-way biological metacrisis that would spawn The Meta-Crisis Tenth Doctor and The Doctor/Donna (DW: Journey's End)
 * Tenth to eleventh incarnation: Sacrificed himself to spare Wilfred Mott, absorbing all the radiation from the nuclear bolt used to power The Immortality Gate. (DW: The End of Time)
 * During eleventh incarnation: The Doctor was shot by a mysterious astronaut. He began to regenerate, but a further shot killed him with the process incomplete. (DW: The Impossible Astronaut)

Alternate Doctors

 * The Doctor: Shot by Ruth after she learned the truth about his role in her father's death; she shot him again when he regenerated and so on. (BFA: Full Fathom Five)

Romana

 * First to Second incarnation: Decided it was time for a change, regenerating into several different forms before settling on the features of Princess Astra. (DW: Destiny of the Daleks)
 * Second to Third incarnation: Regenerated in preparation for the Second War in Heaven, developing a body more suited for combat. (EDA: The Shadows of Avalon)
 * Third to Fourth incarnation: Managed to survive the Second War in Heaven, although this may have entailed a regeneration (PDA: Tomb of Valdemar)
 * Fourth to Fifth incarnation: Implied to have regenerated as a result of her involvement in The Final War in Heaven.
 * Fifth to Sixth incarnation: Regenerated a final time as she fled from Gallifrey's final destruction (possibly with K-9 Mark II in tow).

The Master

 * The Master had used up all 12 of his regenerations, by the time he died on Tersurus. He was able to survive by changing into a decayed form. (DW: The Deadly Assassin)
 * During the Last Great Time War, the Time Lords ressurected the Master, apparently giving him a new regeneration cycle in the process. (DW: Utopia)
 * When The Master was shot by Chantho, he regnerated into a new incarnation.(DW: Utopia)

Rassilon
Rassilon was said to have achieved a cycle of perpetual regeneration, becoming immortal. (DW: The Five Doctors)

K'anpo Rimpoche
Attacked by Eight Legs and regenerated by merging with his assistant Cho Je. (DW: Planet of the Spiders)

Borusa
Borusa regenerated at least 3 times, having at least 4 lives. (DW: The Deadly Assassin, DW: The Invasion of Time, DW: Arc of Infinity, DW: The Five Doctors)

Rallon
Initiated all twelve of his regenerations to stop the Celestial Toymaker. (PDA: Divided Loyalties)

Azmael
Azmael used all his 12 regenerations in unknown circumstances. In his Thirteenth and final body he regenerated past his limit, killing him and Mestor who possessed Azmael's body after his own was destroyed. (DW: The Twin Dilemma)

Iris Wildthyme
Regenerated following a lengthy period of illness following the consumption of a live Kaled mutant. (EDA: The Scarlet Empress)

The War Chief
Underwent a faulty regeneration after being shot by War Lords. This resulted in his new form appearing like two bodies fused together. (NA: Timewyrm: Exodus)

Mortimus
Mortimus regenerated at least once. (NA: No Future, BFA: The Book of Kells)

I.M. Foreman
As a priest, he had been given the gift of regenerations. This made 12 different individuals, who were created from absorbing the DNA around him. (EDA: Interference - Book One, Interference - Book Two)

Little Girl
A little girl regenerated on the streets of New York City in 1970. (DW: Day of the Moon)

The Corsair
The Corsair regenerated several times, with "a couple" of his incarnations being female, he was back to male by the time he was killed by House. (DW: Day of the Moon)

History

 * Regeneration was first introduced when the First Doctor (William Hartnell) changed into the Second Doctor (Patrick Troughton) in the closing moments of The Tenth Planet. Tradition has it that Hartnell himself thought up the idea of the Doctor being able to change into a new body as a means of keeping the series going after his departure. In The Power of the Daleks, the next story, the Doctor said that he had been "renewed", and also said that the change was partly due to the TARDIS, partly to himself, without elaborating. Originally, the production team meant for the Doctor to have used the TARDIS to reverse time and "rejuvenate" himself, though they may have abandoned this explanation by the time Patrick Troughton took over the role.
 * The change in the Doctor's appearance was meant to occur several stories earlier, during The Celestial Toymaker, with the Toymaker capriciously having changed the Doctor's appearance out of spite. (The Doctor is invisible and unable to speak for most of the story anyway.) The reason for the change of plan is unknown. Either it was decided to retain Hartnell in the role for a few more stories, or the actor was accidentally issued with a new contract by mistake, making it impossible to recast the Doctor at that moment in time. (A plot device similar to this would occur in The Mind Robber to cover Frazer Hines' temporary replacement by his cousin, Hamish Wilson, after Hines contracted an illness.)
 * The changeover was not actually referred to as "regeneration" until the end of Planet of the Spiders, when the Third Doctor (Jon Pertwee) changed into the Fourth (Tom Baker). Prior to this, the Doctor was simply described as having "changed his appearance."
 * It is interesting to note that, despite being the Doctor's "greatest enemy", the Daleks have directly or indirectly caused less of the Doctor's regenerations than his own race (the Time Lords). This is because the Daleks have only been in two adventures that forced the Doctor to regenerate (the Eighth to Ninth Doctor regeneration's circumstances is unknown), whereas a Time Lord has had a hand in three of his regenerations.
 * In the original 1963-89 series, plus the 1996 TV movie, each regeneration was treated differently on screen, using a variety of special effects ranging from simple cross-fades to a CGI "morph" in the 1996 film. With the return of Doctor Who in 2005, producer Russell T Davies decided regenerations would take a consistent form, with the Time Lord in question standing upright, arms outstretched, and blinding energy flying out from the head, arms, and legs. So far, the six regenerations depicted on screen (four featuring the Doctor in The Parting of the Ways, The Stolen Earth, The End of Time and The Impossible Astronaut, one featuring the Master in Utopia, and one featuring an unnamed girl in Day of the Moon) have taken on this form.
 * Regeneration has been played for laughs in non-canonical spoofs such as The Curse of Fatal Death, in which the Doctor's repeated accidental deaths enabled five actors to play the role within minutes of one another.

Alternate possibilities
"When they came [to America] to launch The Eleventh Hour, I went along to this screening in LA and journalists put their hands up, and one of the first questions was, "What will happen when he reaches the thirteenth regeneration?" There's a fascinating academic study to be made out of how some facts stick and some don't – how Jon Pertwee's Doctor could say he was thousands of years old, and no-one listens to that, and yet someone once says he’s only got thirteen lives, and it becomes lore. It's really interesting, I think. That's why I’m quite serious that that 507 thing won't stick, because the 13 is too deeply ingrained in the public consciousness. But how? How did that get there? It’s fascinating, it's really weird. Anyway, that'll be my book in my retirement!"
 * Fans and the general public have long speculated as to whether the Doctor could change sex as a result of a regeneration. In Interference - Book One and Book Two, the Time Lord I.M. Foreman was portrayed as having changed sex as a result of regeneration, though the character is noted as having received the gift of regeneration when the process was still experimental and unstable. Female versions of the Doctor appeared in the non-canonical The Curse of Fatal Death and in the Doctor Who Unbound story Exile. In the audio drama The Two Irises, Iris Wildthyme encounters a future, male incarnation of herself. In The End of Time the newly regenerated Doctor shouts out "I'm a Girl!", however this was just seconds after regeneration and it is possible this was post-regenerative trauma. In The Doctor's Wife the Doctor mentioned his friend, The Corsair, who had regenerated as both male and female.
 * In Death of the Doctor the Doctor noted that his racial characteristics were not limited to white; he "can be anything." This is the first reference to such a possibility on-screen, but not in canon; Rassilon has been portrayed by white actors Richard Mathews and Timothy Dalton on-screen while black actor Don Warrington was Rassilon's voice actor and cover-art model in Big Finish Doctor Who audio stories.
 * Russell T Davies noted how firmly the concept of limiting Time Lords to 13 lives, introduced in The Deadly Assassin, was lodged in fans' minds. Davies deliberately broke the limit in Death of the Doctor, though he admits that fandom may resist his attempt to alter the programme's mythos so.

- Russell T Davies