Chen-7

Chen-7, also known as the One Day Plague, was a pathogen capable of killing individuals within the space of a single day. Only species with binary vascular systems, including Apalapucians and Time Lords, could contract the disease, disabling the regeneration cycle in a Time Lord’s case.

When a Chen-7 plague threatened the planet of Apalapucia, the Apalapucians created the Two Streams Facility, which used temporal technology to isolate the patients and stretch out the day into a lifetime. (TV: The Girl Who Waited)