Trenzalore

Trenzalore was the name of a place that, according to Dorium Maldovar, would be where the First Question in the Universe (Doctor Who?) was answered truthfully, and that the Doctor would arrive there at some point in his travels. The religious order known as the Silence was determined to ensure that the Doctor never reached Trenzalore. (DW: The Wedding of River Song)

Dorium also mention that when the Doctor went there it would mean the fall of the Eleventh. (DW: The Wedding of River Song)