The Legend of Pandora's Box

The Legend of Pandora's Box was Amy Pond's favourite book as a child. River Song found it in Amy's room and realised the link with the Pandorica under Stonehenge.

The Doctor suggested that the book was created by aliens using psychic residue as there were landing patterns in Amy's garden. (DW: The Pandorica Opens)

Martha Jones also suggested that the monster DNA hidden in the human genome, which Richard Lazarus accidentally unlocked, was "like Pandora's box." (DW: The Lazarus Experiment)