The Legend of Pandora's Box

The Legend of Pandora's Box was Amy Pond's favourite book as a child. River Song found it in Amy's room and realised the link with the Pandorica under Stonehenge. The Doctor suggested that the book was created by aliens using psychic residue as there were landing patterns in Amy's garden. (TV: The Pandorica Opens)

Martha Jones also suggested that the rejected monstrous DNA hidden in the human genome, which Richard Lazarus accidentally unlocked, was "like Pandora's box." (TV: The Lazarus Experiment)

Romana II, K9 and Irving Braxiatel thought that the legend could be a reference to the first female Lord President and Imperiatrix of Gallifrey, Pandora and her partition of the Matrix, and how she wanted to cause havoc to the continuum. (AUDIO: Lies)