The Sixth Doctor: The Last Adventure

 was a full cast audio anthology released in 2015 by Big Finish Productions, and is notable for being the first time the events leading up to the Sixth Doctor's regeneration have been portrayed in performed media, giving Colin Baker the chance to finally do a regeneration story for his Doctor 28 years after leaving the show. It is also notable for introducing the companion Constance Clarke and seeing the final encounter between the Sixth Doctor and the Valeyard.

The anthology is comprised of four separate stories interspersed throughout different phases of the Sixth Doctor's lifetime, each seeing him travelling with a particular companion, and working progressively further into his life until reaching his final story. The stories can be viewed as one large arc to see how the pieces of the Valeyard's plot all fit together, or viewed independently at the corresponding points of the Sixth Doctor's life in the timeline of his audios and slowly working up to a grand denouement.

Publisher's summary
A very special story which at last provides a heroic exit for Colin Baker's much-loved Time Lord. Four hour-long episodes, connected by the presence of the Valeyard, the entity that exists between the Doctor's twelfth and final incarnations.