2000

January

 * 1 - The Doctor leaves San Francisco, Earth after preventing the Master from destroying the planet at the start of the last year of the millennium. Grace Holloway declines an invitation to travel with him. (DW: Doctor Who)

Spring

 * The Doctor and Romana visit Paris (IDW: The Forgotten), much to Romana's chagrin as they had only just visited the city, albeit 20 years earlier. (DW: City of Death)

August
15th August - Events of BFA: The Shadow of the Scourge.

December

 * 25 - A year prior to this date, the Eighth Doctor warns Chang Lee not to be in San Francisco for Christmas 2000, suggesting knowledge of an event due to take place at this time. The Doctor recommends Chang Lee "take a vacation" on this date, but it's not known if he followed his advice. (DW: Doctor Who)
 * 31st December, end of the 20th century.

Unknown date

 * Sometime after the departure of the Doctor, Grace Holloway discovers residue left over from her encounter with the Master. Seeking out the possibility of developing a Human/Time Lord hybrid capable of regeneration, she begins working for a genetics lab (later she learns she's actually working for a branch of MI6). (DWM: The Glorious Dead)
 * One account claims that it was during the year 2000 that the First Doctor regenerated rather than 1986. (DWN: Doctor Who and the Tenth Planet)

January

 * PDA: Last of the Gaderene is first published.
 * BFA: The Land of the Dead is first released.
 * Donald Cotton, who wrote DW: The Myth Makers and DW: The Gunfighters dies.
 * 03 - EDA: Parallel 59 is first published.
 * 13 - Eric Dodson, who portrayed the role of the headman in DW: The Visitation, dies.

February

 * PDA: Tomb of Valdemar is first published.
 * BFA: The Fearmonger is first released. First solo Seventh Doctor audio adventure.
 * 01 - Reginald Jessup, who played a servant in DW: The Massacre of St Bartholomew's Eve and Lord Savar in DW: The Invasion of Time, dies.
 * 07 - EDA: The Shadows of Avalon is first published. This novel introduces the third incarnation of Romana III.

March

 * BFA: The Marian Conspiracy is first released. This Sixth Doctor adventure features the introduction of Evelyn Smythe, the first companion to be created exclusively for audio.
 * 06 - EDA: The Fall of Yquatine is first published.
 * ST: Short Trips and Side Steps anthology is first published. This is the third and last Short Trips release by BBC Books; Big Finish Productions will later continue the series.

April

 * PDA: Verdigris is first published.
 * BFDE: Dalek Empire: The Genocide Machine is first published, beginning the first multi-part Big Finish story arc.
 * 03 - EDA: Coldheart is first published.

May

 * PDA: Grave Matter is first published.
 * BFA: Red Dawn is first released.
 * 01 - EDA: The Space Age is first published.
 * 15 - Publication of Jon Pertwee: The Biography by Bernard Bale.

June

 * PDA: Heart of TARDIS is first published.
 * BFA: The Spectre of Lanyon Moor is first released.
 * CP: Tales of the Solar System, a Doctor Who short story collection for charity, is first published.
 * REF: The Pocket Essential Doctor Who is first published.
 * 05 - EDA: The Banquo Legacy is first published.
 * 18 - Derek Sydney, who played Sevcheria in DW: The Romans, dies from a heart attack in San Marcos, California.
 * 28 - David Neal (The President in DW: The Caves of Androzani) dies from natural causes.
 * 29 - John Abineri, who had roles in DW: Fury from the Deep, DW: The Ambassadors of Death, DW: Death to the Daleks and DW: The Power of Kroll, dies from motor neurone disease.

July

 * PDA: Prime Time is first published.
 * BFA: Winter for the Adept is first released.
 * 03 - EDA: The Ancestor Cell is first published. Romana III returns. Final appearance of Compassion as a companion.
 * 11 - Roy Purcell (Chief Prison Officer Powers in DW: The Mind of Evil and the President of the Council in DW: The Three Doctors) dies as a result of complications from an operation.

August

 * PDA: Imperial Moon is first published.
 * BFDE: Dalek Empire: The Apocalypse Element is first released. Lalla Ward returns as Romana II and will make many more Big Finish audio dramas in the years ahead.
 * 07 - EDA: The Burning is first published, launching a six-book story arc entitled the Earth Arc. For the next four books, the Doctor has no companions (although this book contains a reference to Compassion).

September

 * PDA: Festival of Death is first published.
 * BFA: The Fires of Vulcan is first released.
 * BFBS: Professor Bernice Summerfield and the Dead Men Diaries is first published, returning Bernice Summerfield to the literary arena and launching the Big Finish Bernice Summerfield Series series of books. This is the first of numerous Summerfield short story collections.
 * Mary Ridge, who directed DW: Terminus dies.
 * Englightenment, the magazine published by the Canadian fan club, the Doctor Who Information Network, publishes its 100th issue.
 * 4 - EDA: Casualties of War is first published.
 * UK release of the remastered and unedited version of DW: An Unearthly Child on home video.

October

 * PDA: Independence Day is first published.
 * BFA: The Shadow of the Scourge is first released.
 * CP: Campaign, a First Doctor novel rejected for the Past Doctor Adventures line, is self-published by its author, Jim Mortimore. According to REF: Howe's Transcendental Toybox, the book was dated May 2000, but did not begin actually circulating until October.
 * 02 - Future Doctor Who co-star Billie Piper releases her second and final album, Walk of Life. After the release of this album, Piper decides to concentrate on her acting career.
 * 12 - EDA: The Turing Test is first published.
 * 14 - Lawrence Davidson, who appeared as the Draconian First Secretary in DW: Frontier in Space dies.
 * 21 - Alan Rowe, who played numerous guest roles on Doctor Who, dies.
 * 25 - REF: Doctor Who: Regeneration is first published.

November

 * PDA: The King of Terror is first published.
 * BFA: The Holy Terror is first released. Frobisher appears, becoming the first character from the Doctor Who Magazine comic strip to appear in a Big Finish audio drama.
 * BFBS: Professor Bernice Summerfield and the Doomsday Manuscript is first published, the first full-length novel in the Big Finish Bernice Summerfield Series of books.
 * 06 - EDA: Endgame is first published.
 * 23 - REF: Howe's Transcendental Toybox first published.

December

 * BFDE: Dalek Empire: The Mutant Phase is first released.
 * Morris Barry, who directed DW: The Moonbase, DW: The Tomb of the Cybermen and DW: The Dominators, as well as playing Tollund in DW: The Creature from the Pit dies.
 * 17 - Maurice Quick, who played the Gold Usher in DW: The Deadly Assassin dies.
 * 21 - John Lee, who portrayed Alydon in DW: The Daleks, dies in Melbourne, Australia.