Grand Matriarch

The Grand Matriarch was the ruler of the Panjistri. She was originally named Lilith, but over time came to refer to herself almost exclusively by her title.

Biography
When Lilith was a little girl, she encountered the Second Doctor, who was looking for his friend Polly. Lilith told him where she had gone, and in return he repaired her doll and played his recorder for her. Unknown to him at the time, the weakened Timewyrm, who had gone back into the Doctor's personal timeline and was hiding inside him, transferred herself to Lilith.

Lilith became the leader of the Panjistri who were selected to leave their homeworld in their spacecraft, Kandasi, and embark on a mission to prevent the end of the Universe. After five thousand years (the Timewyrm having greatly extended the Grand Matriarch's lifespan), the God Machine was nearly completed when the Seventh Doctor and Ace arrived on Kirith. Recognizing the Time Lord, the Grand Matriarch and her Companion Fetch observed them, and when the Homunculus was killed, she decided to have Ace be made part of the God Machine. The Grand Matriarch, now fully possessed by the Timewyrm, captured Ace and began preparing her mind for the process, but was confronted by the Doctor, who recognized her. However, Raphael, having merged with the God Machine, banished the Timewyrm from her, causing her to rapidly age and die. (NA: Timewyrm: Apocalypse)