1665

In 1665, the first cases of what would become known as the Great Plague of London appeared on the city's outskirts. The disease became more widespread and fatal the following year, after a deadlier strain of the bacterium Yersinia pestis was engineered by a group of escaped Terileptil criminals.

As a precaution against the spreading plague, King Charles II ordered the theatres closed. This put actor Richard Mace out of work, causing him to become a highwayman. (DW: The Visitation)

The Fifth Doctor and Nyssa visited Suffolk in 1665. (BFA: The Demons of Red Lodge)