River Nile

The River Nile was in Egypt.

History
The Eighth Doctor travelled down the Nile with Ediphis. The Osirian, Thoueris, hid in the Nile. She could control the Crocodiles there with a ring. (DWM: The Power of Thoueris!)

The Sixth Doctor and Peri Brown saw Cleopatra's barge travel down the Nile. (MA: State of Change)

During the alternate timeline of The Year That Never Was, the Master had the Nile frozen over. (DW: Last of the Time Lords)

In another alternate timeline, penguins lived on the Nile. (DW: The Big Bang)