Sentient oil

A puddle of sentient oil was left behind by a spaceship that had previously landed in Bristol. The oil was able to mimic other beings, survive a blast from a Dalek gun, target passengers and follow them across time and space. Although it doesn't have any intention to kill, it was implied to have "eaten" Heather.

Heather had previously come across the puddle around St Luke's University, noticing something strange about her reflection. She took Bill with her to show her the puddle, and Bill knew something was different about her reflection but couldn't determine what was wrong since her appearance was symmetrical that day.

Bill told the Twelfth Doctor about the puddle, and before she could finish explaining the Doctor had already begun to run to the site. The Doctor quickly discovered what was off about the reflection, which was that it was showing the reflection in the other way to a mirror and everything was in the right place. Bill's patch on her clothing was opposite of its placement. The Doctor also noticed scorch marks in a circular pattern surrounding the puddle, but claimed he was bored to lead Bill away. As they left, the oil started creeping away from its spot. Bill later saw the oil in her bathroom, now taking the form of Heather.

Bill ran to St Luke's only to find the oil there again, repeating everything Bill was saying to her. Bill ran into the Doctor's office and shut the door behind her, locking it in place with a chair. The puddle managed to flow underneath the door and reappear as Heather again. The Doctor lead Bill into the TARDIS and travelled to the vault. After realizing that the oil was after them and not the vault, they ran back to the TARDIS and landed in Sydney, where the oil appeared as well.

Determined to find the limitations of the oil, the Doctor travelled 23 millions years into the future onto another planet. The oil followed them through time to this planet as well. The Doctor and Bill went back into the TARDIS and landed in the middle of a Dalek-Movellan War to get a Dalek to exterminate the oil.

A Dalek shot the oil but it easily survived the attack, repeating the Dalek's "exterminate" phrase whilst doing so. The Doctor and Heather were trapped by a Dalek but it was revealed to be the oil having taken the form of a Dalek, although with Heather's star eye. It transformed again into Heather. The Doctor realised that the oil didn't want to kill, but wanted Bill to travel with it. Bill remembered that she asked Heather to promise that she wouldn't leave her, so this was the last thought Heather had before being eaten by the oil. Bill told the oil to let her go, the oil resumed its puddle form and remained at the war zone. (TV: The Pilot)