1665

Events

 * The first cases of what will be known as the Great Plague of London appear in the city's outskirts. The disease will become more widespread and fatal the following year, after the plague bacteria are genetically augmented by a group of escaped Terileptil criminals. As a precaution against spreading the plague, King Charles II orders the theaters closed, an act which puts actor Richard Mace out of work, forcing him to become a highwayman ("The Visitation").