Reality bomb

The reality bomb was a superweapon created by Davros for use by the Daleks. It had the potential to annihilate all matter in every universe.

History
The weapon made use of the stolen planets transported to the Medusa Cascade, captured by the New Dalek Empire, along with the unique Z-Neutrino-based energy source of the Crucible. This bomb worked by cancelling out the holding atoms together, and was capable of wiping out the entire universe and all of creation, except for those within or near the Crucible, fulfilling the Daleks' stated goal of wiping out all other life in the universe many times over. Once the weapon penetrated the time rift at the heart of the Medusa Cascade, it would spread into every parallel universe and alternate dimension (even the Void) as well. The reality bomb was planned to destroy all other forms of life in every universe — except for the Daleks, allowing for them to be only race in all of existence.

The reality bomb was actually an electromagnetic cancelling wave, the emitters of which were several large, luminous green hemispheres set into the exterior hull of the Crucible. Each hemisphere was contained within a ring of panels which resembled the slats on a Dalek casing. There was a smaller scale version located inside the Crucible which was used for a successful test firing on a group of humans.

The Tenth Doctor and his companions were successful in preventing the use of the weapon on a large scale. It was shut down using an internalised synchronous back-feed reversal loop, and then destroyed when the Crucible exploded. (TV: Journey's End) The reality bomb weakened the dimensional walls, allowing some of the Cybermen that were trapped in the Void during the Battle of Canary Wharf to escape. The rest, along with the Daleks that also fought in the battle, perished, according to the Doctor. (TV: The Next Doctor)

In a parallel universe where the Doctor died defeating the Racnoss, the Daleks were successful in detonating the reality bomb, at which point all life in that universe began to disappear from existence, resulting in the ultimate worst-case scenario. This was observed from Earth as the stars in the night sky "going out". (TV: Turn Left)