Tenth Doctor's hand

The Doctor's hand was the severed right hand of the Doctor which he lost shortly after his regeneration into his tenth incarnation.

History
After the Ninth Doctor regenerated into his tenth incarnation, the hand was attached to his arm. The newly-regenerated Doctor noted a "slight weakness in the dorsal tubercle" around his hand, but this was not mentioned again during the remainder of the time this hand was attached to his body. (DW: Children in Need Special)

During a sword fight with the Sycorax leader on the deck of their ship, the leader cut the Doctor's right hand off and it fell somewhere in London. Because he was within the first fifteen hours of his regeneration, he regrew the hand. (DW: The Christmas Invasion) After Captain Jack Harkness travelled from 200,100 to 1869, he eventually found the hand and used it to detect the Doctor whenever he came to the Cardiff Rift to refuel, hoping to find a version of the Doctor which coincided with his own timeline. (DW: Utopia) The precise details of how it detected the presence of the Doctor are unknown. Jack kept the hand preserved in a jar which he kept on his desk. Despite being severed, it did not decay and continued to move and twitch. (TW: Day One)

When Carys Fletcher escaped, she broke the jar, distracting Jack enough for her to escape. (TW: Day One)

When the Doctor arrived at Cardiff Bay, the hand started to react, glowing and moving. (TW: End of Days) After the Doctor came to refuel at the Rift, Captain Jack joined the Doctor and brought the severed hand with him. After travelling to the year 100,000,000,000,000, the Doctor, Martha Jones, and Jack met Professor Yana, who then became the Master. He took the Doctor's hand from Jack and escaped in the Doctor's TARDIS after he regenerated. (DW: Utopia)

The Doctor fixed Jack's Vortex Manipulator so they could travel to 2008. When they encountered the Master, he revealed that he put Richard Lazarus' genetic technology into his laser screwdriver. Using the Doctor's biological code he had gained from the hand, the Master aged the Doctor a hundred years. (DW: The Sound of Drums) The Year That Never Was followed, after which the Doctor reclaimed his severed hand and kept it aboard his TARDIS in the control room. (DW: Last of the Time Lords)

After the Sontaran invasion of Earth, the TARDIS set off by itself to Messaline, with the hand apparently reacting to Jenny's later birth. (DW: The Poison Sky, The Doctor's Daughter)

The Doctor's hand remained in his TARDIS and was present for the Doctor's apparent regeneration when he was shot by a Dalek. (DW: The Stolen Earth) After the Doctor had healed from the damage caused by the shot, he channelled the excess regenerative energy that would have changed his appearance into a bio-matching receptacle, his hand, leaving him healed while remaining in his tenth incarnation. (DW: Journey's End)

However, Donna touched the energised hand, which caused a new version of the Doctor to be generated. The new Meta-Crisis Doctor had the intelligence of the original Doctor mixed with Donna's persona and attitude. (DW: Journey's End)

Behind the scenes

 * David Tennant provided the cast for the hand during the filming of Utopia. This cast was retained during the remainder of the prop's time on the show.