Grace Holloway

Dr. Grace Holloway was a San Francisco cardiologist and the first companion of the Eighth Doctor. She was a member of the board of trustees of the Institute for Technological Advancement and Research.

Biography
Dr. Holloway was known as "Amazing Grace" by her colleagues at Walker General Hospital, where she worked as an on-call cardiologist. The "on-call" part of the job description was particularly annoying to her live-in boyfriend, Brian.

Meeting the Doctor
On the evening of 30 December 1999, Grace was attending the opera when she received a page and rushed to the hospital to deal with an unusual cardiac case that had come in - a middle-aged man who had suffered minor bullet wounds but who apparently had a heart defect that caused a very irregular heart beat.

Unknown to Grace, her patient had been x-rayed earlier and appeared to have two hearts. While conducting exploratory surgery with a fibre-optic camera, she could not navigate within the man's circulatory system. She inadvertently caused a fatal injury to him and he died on the operating table. Upset at losing a patient, an event witnessed by the hospital's financial supporters, Grace ordered an autopsy. Due to the incident, complicated by the fact the man's body subsequently disappeared from the morgue, Holloway resigned the next morning under pressure. Her boyfriend also left her.

While she was leaving the hospital, a strange man followed her, claiming to be the man who had died the night before. At first Grace refused to believe him, but was convinced when he took the remains of her probe from his chest. She learned he had undergone regeneration which had changed his appearance and personality, but due to his being under anaesthetic at the time, he was suffering total amnesia. Hours later, he suddenly regained his memories of being the Doctor, a Time Lord, and he celebrated the return of his memories by kissing Grace.

With his memories restored, the Doctor enlisted Grace to help him defeat the Master, his enemy. During this time she exclaimed she'd finally found the right guy, only to discover "he's from another planet!"

She was possessed for a short while by the Master, while she betrayed the Doctor. She later unwillingly opened the Eye of Harmony inside the TARDIS and was killed, but the TARDIS used the Eye to bring her back to life.

After the Master's defeat, the Doctor invited Grace to travel with him as a companion, but she declined. After sharing a romantic kiss with her, the Doctor departed in the TARDIS and each of them went their separate ways. (DW: Doctor Who)

After the Doctor
After the Doctor's departure, Grace began examining the remnants of a substance the Master spat at her during the battle, which led her to working with an MI6-sponsored genetics lab in hopes of creating a human-Time Lord hybrid capable of regeneration. When Holloway was later reunited with the Doctor, he chastised her for this, though they ultimately reconciled and parted company with another kiss. (DWM: The Fallen)

Grace Holloway's ultimate fate is unknown, but the Doctor indicated that he was familiar with her work and that she was destined to do "great things". (DW: Doctor Who) Holloway interpreted this as being a reference to her work with MI6 on the human/Time Lord hybrid. (DWM: The Fallen) Her longterm impact on the Doctor is evident in that sometime later, he experienced a hallucination that he and Grace were married. (DWM: The Glorious Dead) She survived the Cyberman invasion of Earth in 2004 and concluded that the Doctor must have stopped them. (DWM: The Flood)

Habits and quirks
Grace expressed an interest in Puccini's operas and the art of da Vinci. (DW: Doctor Who)

Behind the scenes

 * Grace at one point exclaimed, "I finally found the right guy and he's from another planet!". Although the 1963-89 series occasionally gave subtle hints of attraction and even romance between the Doctor and other characters, this is the first time a character, identified as a companion, had been heard to directly express attraction towards the Doctor on screen.
 * According to media coverage of the film in 1996, had Doctor Who been revived as a series at that time, the character of Grace Holloway would not have continued as a regular companion.
 * In the video game Bioshock 2 there is a character also called Grace Holloway.